What is CBC?
Have you heard of Cannabichromene ? Also known as CBC ? This cannabinoid was discovered nearly 50 years ago and is considered one of the big six cannabinoids which are prevalent in medical research today. Although it doesn’t get as much attention as THC or CBD the benefits of CBC are just as promising .
CBC has the same origins as THC and CBD in that they all stem from CBGA ( cannabigerolic acid) . Cannabis plants produce CBGA as a precursor to the three major cannabinoids, Tetrahydrocannabinolic acid (THCA), Cannabidiolic Acid (CBDA) and cannabichromenic Acid (CBCA) . Plant enzymes control the breakdown product into one of the three lines. CBC is converted from CBGA into CBCA and then finally CBC after exposure to heat or UV light .
What is CBC? CBC is non-intoxicating , so it doesn’t produce the euphoric high like THC. The reason behind this is that it binds poorly to CB1 receptors in the brain. However it is able to bind to other receptors in the body sauch as the Vanilloid receptor 1 (TRPV1) and the transient receptor potential ankyrin 1 (TRPA1) both these receptors are linked to pain perception. When CBC activates these receptors increased levels of the bodies natural endocannabinoids like anandamide are released . While CBC definitely has singular benefits , researches believe that it is also important as part of the entourage effect. This effect of THC and CBD working together is well known but if other cannabinoids have entourage effects is not yet well understood.
The benefits of CBC have far reaching implications . Cannabichromene may be powerful against cancer due to the way it interacts with the bodys own endocannabinoid anandamide. CBC also appears to inhibit the uptake of anandamide , allowing it to remain for longer periods in the bloodstream. A recent study into tumour growth showed that cannabinoids may be effective in inhibiting both inflammation and tumour growth. Anandamide has been shown to successfully fight breast cancer in vitro and in vivo , one day cannabinoids such as CBC may be used as a chemopreventive agent.
CBC as a potential cancer fighter was first studied in 2006. The study looked at cannabinoids other than THC and their possible effects on cancer. THC is well known for its anti-tumor properties for several types of cancer, its potent psychotropic qualities can make it difficult for chemotherapy use . CBG is the most potent cannabinoid for inhibiting cancer cell growth, however research shows that CBC is the second most potent .
CBC has been shown to be excellent at blocking pain and reducing inflammation in cases of osteoarthritis. CBC acts on inflammation in a different way to non-steriodal anti-inflammatory drugs (NSAIDS) and CBC does not have the side effects of these medications. In an example of the entourage effect CBC and THC worked together during a recent study and together the two cannabinoids produced a much more significant effect on inflammation than by themselves.
During a study in 2013 CBC had a very promising effect on neural stem progenitor cells (NSPCs) . These cells have an essential role in healthy brain function. NSPCs became significantly more viable when CBC was introduced , this is extremely promising as NSPCs differentiate into Astroglial cells , these are the premier cells for maintaining brain homeostasis. Astroglial cells perform a wide array of functions including neurotransmitter direction and defending against oxidative stress. Asroglial cells counteract these issues that can create neurological diseases such as Alzheimers disease.
Further reserch using CBC includes the use of cannabinoids on the treatment of acne . CBC was shown to be a powerful inhibitor of Acne . Acne is characterised by excessive sebum production along with sebaceous gland inflammation. CBC exhibited powerful anti-inflammatory properties and was able to suppress lipid production within the sebaceous gland . CBC also reduced Arachidonic Acid (AA) which is required to produce lipogenesis. More research is required , but CBC may just become a powerful anti-acne treatment.
In another mazing example of the entourage effect CBC works in conjunction with THC and CBD to deliver an effective trifecta of antidepressant properties. The therapeutic properties of CBC are important and more research is required to determine its power by itself and working alongside other cannabinoids together for an entourage effect. Patients today are limited to the treatments available to them, however as new studies take place hopefully cannabis laws will loosen and new medicines with a wide range of cannabinoids will become a viable option for many.